CD47 and P2RY2

Number of citations of the paper that reports this interaction (PubMedID 11331301)
45

Data Source:
HPRD (in vivo)

		CD47	P2RY2
Description		CD47 molecule	purinergic receptor P2Y2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Cell Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity	Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	Inflammatory Response Integrin-mediated Signaling Pathway Opsonization Positive Regulation Of Cell Proliferation Response To Bacterium Cell Migration Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Monocyte Aggregation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Cellular Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Regulation Of Blood Vessel Diameter
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	G alpha (q) signalling events P2Y receptors Surfactant metabolism
Drugs			Suramin Denufosol INS 316
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 25673413) Regular attendance at a religious group ( 29970889)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		12 interacting genes: BNIP3 EPB42 FAS GNAI1 ITGAV P2RY2 PTK2 RHAG SIRPA SYNE4 THBS1 UBQLN1	7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC
Entrez ID		961	5029
HPRD ID		03017	02499
Ensembl ID		ENSG00000196776	ENSG00000175591
Uniprot IDs		A0A0A1TSG4 Q08722	P41231
PDB IDs		2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU	1Z8E
Enriched GO Terms of Interacting Partners?
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