P2RY2 and CD47

Number of citations of the paper that reports this interaction (PubMedID 11331301)
45

Data Source:
HPRD (in vivo)

		P2RY2	CD47
Description		purinergic receptor P2Y2	CD47 molecule
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Cellular Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Regulation Of Blood Vessel Diameter	Inflammatory Response Integrin-mediated Signaling Pathway Opsonization Positive Regulation Of Cell Proliferation Response To Bacterium Cell Migration Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Monocyte Aggregation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		G alpha (q) signalling events P2Y receptors Surfactant metabolism	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs		Suramin Denufosol INS 316
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)	Bipolar disorder ( 31043756) Body mass index ( 25673413) Regular attendance at a religious group ( 29970889)
Interacting Genes		7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC	12 interacting genes: BNIP3 EPB42 FAS GNAI1 ITGAV P2RY2 PTK2 RHAG SIRPA SYNE4 THBS1 UBQLN1
Entrez ID		5029	961
HPRD ID		02499	03017
Ensembl ID		ENSG00000175591	ENSG00000196776
Uniprot IDs		P41231	A0A0A1TSG4 Q08722
PDB IDs		1Z8E	2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU
Enriched GO Terms of Interacting Partners?
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