GTF2IRD1 and ALMS1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
6

Data Source:
BioGRID (two hybrid)

		GTF2IRD1	ALMS1
Description		GTF2I repeat domain containing 1	ALMS1 centrosome and basal body associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Spindle Pole Centrosome Centriole Cytosol Cilium
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Molecular_function Protein Binding Microtubule Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Multicellular Organism Development Transition Between Slow And Fast Fiber	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Endosomal Transport Regulation Of Centriole Replication Regulation Of Stress Fiber Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases			Alstrom syndrome (AS)
GWAS		Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Severe influenza A (H1N1) infection ( 26379185) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469)	Age at voice drop ( 27182965) Blood metabolite levels ( 26401656) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Intelligence (MTAG) ( 29326435) Menarche (age at onset) ( 27182965) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		22 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5	3 interacting genes: GTF2IRD1 LIG4 MEGF10
Entrez ID		9569	7840
HPRD ID		08379	06023
Ensembl ID		ENSG00000006704	ENSG00000116127
Uniprot IDs		E9PFE2 Q9UHL9	Q8TCU4
PDB IDs		2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?
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