ALMS1 and GTF2IRD1

Number of citations of the paper that reports this interaction (PubMedID 26275350)
6

Data Source:
BioGRID (two hybrid)

		ALMS1	GTF2IRD1
Description		ALMS1 centrosome and basal body associated protein	GTF2I repeat domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Centriole Cytosol Cilium	Nucleus Nucleoplasm Cytosol
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Endosomal Transport Regulation Of Centriole Replication Regulation Of Stress Fiber Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Multicellular Organism Development Transition Between Slow And Fast Fiber
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Alstrom syndrome (AS)
GWAS		Age at voice drop ( 27182965) Blood metabolite levels ( 26401656) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Intelligence (MTAG) ( 29326435) Menarche (age at onset) ( 27182965) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites (H-NMR features) ( 24586186)	Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Severe influenza A (H1N1) infection ( 26379185) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469)
Interacting Genes		3 interacting genes: GTF2IRD1 LIG4 MEGF10	22 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		7840	9569
HPRD ID		06023	08379
Ensembl ID		ENSG00000116127	ENSG00000006704
Uniprot IDs		Q8TCU4	E9PFE2 Q9UHL9
PDB IDs			2D99 2DN5 2DZQ 2DZR
Enriched GO Terms of Interacting Partners?
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