APBA3 and BCR

Number of citations of the paper that reports this interaction (PubMedID 15494376)
6

Data Source:
HPRD (in vivo, in vitro)

		APBA3	BCR
Description		amyloid beta precursor protein binding family A member 3	BCR activator of RhoGEF and GTPase
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Synapse Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Postsynaptic Density Membrane Cell Junction Axon Protein-containing Complex Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity	Negative Regulation Of Cellular Extravasation Renal System Process Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Brain Development Actin Cytoskeleton Organization Keratinocyte Differentiation Regulation Of Rho Protein Signal Transduction Inner Ear Morphogenesis Regulation Of Vascular Permeability Negative Regulation Of Neutrophil Degranulation Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Definitive Hemopoiesis Negative Regulation Of Respiratory Burst Negative Regulation Of Blood Vessel Remodeling Intracellular Protein Transmembrane Transport Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Neurexins and neuroligins	Signaling by cytosolic FGFR1 fusion mutants Rho GTPase cycle Signaling by FGFR1 in disease
Drugs			Dasatinib Bosutinib Ponatinib
Diseases			Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS			Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369)
Interacting Genes		8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1	45 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		9546	613
HPRD ID		05038	01044
Ensembl ID		ENSG00000011132	ENSG00000186716
Uniprot IDs		O96018	P11274
PDB IDs		2YT7 2YT8 5UWS	1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?
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