KIF23 and USP8

Number of citations of the paper that reports this interaction (PubMedID 18329369)
73

Data Source:
HPRD (in vivo)

		KIF23	USP8
Description		kinesin family member 23	ubiquitin specific peptidase 8
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Focal Adhesion Midbody Intercellular Bridge Mitotic Spindle Flemming Body Centralspindlin Complex	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Mitotic Spindle Elongation Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Plus-end-directed Vesicle Transport Along Microtubule	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Mitotic Telophase/Cytokinesis Kinesins	Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
Drugs
Diseases
GWAS		Rheumatoid arthritis (ACPA-positive) ( 24532676)	Ankylosing spondylitis ( 30946743) Heel bone mineral density ( 30598549)
Interacting Genes		11 interacting genes: ACTA1 ARF3 CLK1 LATS2 PLK1 RACGAP1 RBM34 USP8 YWHAB YWHAG YWHAQ	40 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ
Entrez ID		9493	9101
HPRD ID		05455	04405
Ensembl ID		ENSG00000137807	ENSG00000138592
Uniprot IDs		Q02241	A0A024R5S4 A8K8N5 P40818
PDB IDs		3VHX	1WHB 2A9U 2GFO 2GWF 3N3K 6F09
Enriched GO Terms of Interacting Partners?
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