SCARB1 and SNAP23

		SCARB1	SNAP23
Description		scavenger receptor class B member 1	synaptosome associated protein 23
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Endocytic Vesicle Membrane Microvillus Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Cell Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Adherens Junction Focal Adhesion Phagocytic Vesicle Membrane SNARE Complex Specific Granule Membrane Specific Granule Azurophil Granule Mast Cell Granule Neuron Projection Extracellular Exosome Tertiary Granule Membrane Presynapse
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Receptor Activity Scavenger Receptor Activity Transporter Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Identical Protein Binding High-density Lipoprotein Particle Receptor Activity	SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Endothelial Cell Proliferation Androgen Biosynthetic Process Cholesterol Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Viral Entry Into Host Cell Regulation Of Phagocytosis Intestinal Absorption Positive Regulation Of Nitric-oxide Synthase Activity Triglyceride Homeostasis Cholesterol Import	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Histamine Secretion By Mast Cell Exocytosis Post-Golgi Vesicle-mediated Transport Vesicle Targeting Vesicle Fusion Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Neutrophil Degranulation Membrane Fusion
Pathways			ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Neutrophil degranulation
Drugs		Phosphatidyl serine
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 31217584) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 20442857) Lung function (FEV1) ( 30061609) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels (lipoprotein measures) ( 27005778) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Total bilirubin levels ( 29403010) Total cholesterol levels ( 29403010) Triglycerides ( 30275531) Vitamin E levels ( 21729881)	Bipolar disorder ( 31043756)
Interacting Genes		16 interacting genes: APOA1 APOA2 APOE CASP10 DENR GGA1 GTF2H3 KRTAP10-9 KRTAP5-9 PDZK1 PEX5 POLE PRL PXN SNAP23 SRSF9	33 interacting genes: ABI2 ABI3 CFTR FXR2 ITSN1 KIF5B MATR3 NAPA NAPB PRKCA SCAMP1 SCAMP2 SCARB1 SCGN SNAPIN SNTG1 STX11 STX12 STX1A STX1B STX3 STX4 STX5 STX6 STXBP2 STXBP5 TLK1 VAMP1 VAMP2 VAMP3 VAMP7 VAMP8 WASH2P
Entrez ID		949	8773
HPRD ID		03024	03962
Ensembl ID		ENSG00000073060	ENSG00000092531
Uniprot IDs		A0A024RBS4 Q8WTV0	A0A024R9R8 A8K287 O00161
PDB IDs			1NHL 3ZUS
Enriched GO Terms of Interacting Partners?
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