IL27RA and GDF15

		IL27RA	GDF15
Description		interleukin 27 receptor subunit alpha	growth differentiation factor 15
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Cytokine Binding Interleukin-27 Receptor Activity	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Tumor Necrosis Factor Secretion Negative Regulation Of Interleukin-17 Secretion Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		5 interacting genes: EBI3 GDF15 IL27 MAPK8 STAT1	16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1
Entrez ID		9466	9518
HPRD ID		09247	05608
Ensembl ID		ENSG00000104998	ENSG00000130513
Uniprot IDs		Q6UWB1	Q99988
PDB IDs			5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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