GDF15 and PDE4C

		GDF15	PDE4C
Description		growth differentiation factor 15	phosphodiesterase 4C
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Cytosol Cilium
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	CAMP Catabolic Process G Protein-coupled Receptor Signaling Pathway
Pathways			DARPP-32 events G alpha (s) signalling events
Drugs			Caffeine Dyphylline Iloprost Roflumilast Piclamilast Crisaborole Ibudilast Trapidil
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)	Urate levels ( 31578528)
Interacting Genes		16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1	2 interacting genes: GDF15 SRI
Entrez ID		9518	5143
HPRD ID		05608	02529
Ensembl ID		ENSG00000130513	ENSG00000105650
Uniprot IDs		Q99988	O43849 P78505 Q08493 Q32MM7 Q7KYS4
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	1LXU 2QYM
Enriched GO Terms of Interacting Partners?
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