MED23 and NCOA6

Number of citations of the paper that reports this interaction (PubMedID 10823961)
40

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MED23	NCOA6
Description		mediator complex subunit 23	nuclear receptor coactivator 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex Mediator Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coactivator Activity Protein Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Hormone Receptor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Nucleic Acid-templated Transcription	DNA-templated Transcription, Initiation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Regulation Of Lipid Metabolic Process Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		L-arginine levels ( 25245031) Type 2 diabetes ( 30054458)	Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: CEBPB CTDP1 ELF3 ESR1 ESR2 ETS1 FOXJ3 MED13 MED9 NCOA6 PUM2 RELA SREBF1 VDR WDTC1	63 interacting genes: AAR2 AR ASCC1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335
Entrez ID		9439	23054
HPRD ID		05436	05599
Ensembl ID		ENSG00000112282	ENSG00000198646
Uniprot IDs		Q05DL5 Q9ULK4	F6M2K2 F6M2K3 Q14686
PDB IDs		6H02
Enriched GO Terms of Interacting Partners?
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