NCOA6 and THRB

Number of citations of the paper that reports this interaction (PubMedID 10567404)
67

Data Source:
BioGRID (two hybrid, two hybrid, pull down)
HPRD (two hybrid)

		NCOA6	THRB
Description		nuclear receptor coactivator 6	thyroid hormone receptor beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Factor Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Transcription Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Hormone Receptor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Signaling Receptor Activity Thyroid Hormone Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	DNA-templated Transcription, Initiation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Regulation Of Lipid Metabolic Process Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Mediated Signaling Pathway Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Cell Differentiation Thyroid Gland Development Response To Lipid Negative Regulation Of Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Type I Pneumocyte Differentiation Retinal Cone Cell Apoptotic Process
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Chronotype ( 30696823) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin ( 29403010 20139978 27863252 28017375) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 29403010 20139978 27863252 28017375) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 27863252) Myopia ( 27182965) Red blood cell count ( 29403010 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526)
Interacting Genes		63 interacting genes: AAR2 AR ASCC1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335	59 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PDE4DIP PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3
Entrez ID		23054	7068
HPRD ID		05599	07521
Ensembl ID		ENSG00000198646	ENSG00000151090
Uniprot IDs		F6M2K2 F6M2K3 Q14686	A0A024R2I8 P10828
PDB IDs			1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW
Enriched GO Terms of Interacting Partners?
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