EPSTI1 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		EPSTI1	BAG4
Description		epithelial stromal interaction 1	BAG cochaperone 4
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytosol Plasma Membrane
	Molecular Function		RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process		Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Ruffle Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Pathways			Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS		Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Dimensional psychopathology (Arousal) ( 29496196) Heel bone mineral density ( 30598549) Irritable bowel syndrome ( 29626450) Obesity-related traits ( 23251661) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309) Severe aplastic anemia ( 32004448)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		13 interacting genes: AKT1 AURKA BAG4 BCAR3 CASP8 ESR1 FGFR4 FZR1 NOTCH2 PPM1D PTPRJ RB1CC1 VCP	38 interacting genes: APOBEC1 ATAD2 BAP1 BCAS3 BCL2 BEX1 CASZ1 CCL5 DIRAS3 EPSTI1 ERRFI1 GLCE GRAP2 HSPA1A HSPA8 IL13RA2 IL24 ITIH5 KLK5 KLK7 KLK9 LRATD2 LYPD3 MRC2 MTA3 NAT2 PDLIM2 PLAT PRDM14 RASL10B RHOBTB2 RNF20 RPL22 SCGB3A1 TBC1D7 THRSP TNFRSF1A TNFRSF25
Entrez ID		94240	9530
HPRD ID		06309	04861
Ensembl ID		ENSG00000133106	ENSG00000156735
Uniprot IDs		Q96J88	O95429
PDB IDs			1M62 1M7K
Enriched GO Terms of Interacting Partners?
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