SYTL4 and RAB27B

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		SYTL4	RAB27B
Description		synaptotagmin like 4	RAB27B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle	Cell Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Endomembrane System Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm
	Molecular Function	Protein Binding Phospholipid Binding Rab GTPase Binding Neurexin Family Protein Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair	Platelet Degranulation Intracellular Protein Transport Melanosome Transport Rab Protein Signal Transduction Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Platelet degranulation	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Insulin Human Insulin Pork
Diseases
GWAS		Lean body mass ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		12 interacting genes: CCDC85B CEP70 FXR2 HMG20A INS RAB27A RAB27B RAB3A RAB8A STX1A STXBP1 ZBTB7B	8 interacting genes: DHPS MLPH RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D
Entrez ID		94121	5874
HPRD ID		06735	04846
Ensembl ID		ENSG00000102362	ENSG00000041353
Uniprot IDs		A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24	O00194
PDB IDs		2CSZ 3FDW 5X6T	2F7S
Enriched GO Terms of Interacting Partners?
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