MED21 and BLOC1S6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MED21	BLOC1S6
Description		mediator complex subunit 21	biogenesis of lysosomal organelles complex 1 subunit 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mediator Complex	Cell Cytoplasm Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex Presynapse Axon Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Blastocyst Development Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Stem Cell Population Maintenance RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II	Anterograde Axonal Transport Synaptic Vesicle Docking Neuron Projection Development Melanosome Transport Melanosome Organization Endosome To Melanosome Transport Intracellular Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		26 interacting genes: BLOC1S6 BRCA1 BTF3 CDK8 CDK9 ELOA ESR1 ESR2 HNF4A HTT MAGEA6 MAGEB4 MED29 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 VAV2 ZNF655 ZSCAN1	38 interacting genes: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 CCDC136 CCDC22 CCHCR1 CDK5R1 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 KRT13 LURAP1 MED21 NDC80 NDN NTAQ1 NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 SKA1 SLC4A1 SMN2 SNAPIN STX11 STX12 SYCE3 TPM3 WASHC3
Entrez ID		9412	26258
HPRD ID		09156	16055
Ensembl ID		ENSG00000152944	ENSG00000104164
Uniprot IDs		A0A024RAW0 Q13503	B3KY40 H3BST1 Q9UL45
PDB IDs
Enriched GO Terms of Interacting Partners?
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