GTF3C5 and TCF21

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		GTF3C5	TCF21
Description		general transcription factor IIIC subunit 5	transcription factor 21
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleoplasm	Nuclear Chromatin Nucleus
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Histone Deacetylase Binding BHLH Transcription Factor Binding Protein Dimerization Activity Androgen Receptor Binding E-box Binding
	Biological Process	Transcription By RNA Polymerase III Skeletal Muscle Cell Differentiation 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III RNA Polymerase III Preinitiation Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Branching Structure Kidney Development Vasculature Development Regulation Of Transcription By RNA Polymerase II Sex Determination Branchiomeric Skeletal Muscle Development Epithelial Cell Differentiation Developmental Process Glomerulus Development Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Spleen Development Embryonic Digestive Tract Morphogenesis Reproductive Structure Development Gland Development Sertoli Cell Differentiation Roof Of Mouth Development Lung Morphogenesis Lung Vasculature Development Bronchiole Development Diaphragm Development Respiratory System Development Negative Regulation Of Androgen Receptor Signaling Pathway Metanephric Mesenchymal Cell Differentiation Metanephric Glomerular Capillary Formation
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS			Blood pressure traits (multi-trait analysis) ( 28498854) Blood urea nitrogen levels ( 31152163) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22751097 21378990) Diastolic blood pressure ( 28498854) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pulse pressure ( 28498854) Systolic blood pressure ( 28498854)
Interacting Genes		13 interacting genes: BRF1 DNMT3L GTF3C3 GTF3C4 GTF3C6 KRT40 KRTAP10-3 MDFI NOTCH2NLA SRA1 TBP TCF21 TCF4	7 interacting genes: APEX1 APLP1 GTF3C5 HOXB6 KLF15 LMO4 TCF3
Entrez ID		9328	6943
HPRD ID		16077	04493
Ensembl ID		ENSG00000148308	ENSG00000118526
Uniprot IDs		H7BY84 Q9Y5Q8	O43680
PDB IDs
Enriched GO Terms of Interacting Partners?
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