MMP20 and ACAN

Number of citations of the paper that reports this interaction (PubMedID 10922468)
29

Data Source:
HPRD (in vitro)

		MMP20	ACAN
Description		matrix metallopeptidase 20	aggrecan
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Basement Membrane Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Enamel Mineralization Amelogenesis	Skeletal System Development Cartilage Condensation Chondrocyte Development Proteolysis Cell Adhesion Central Nervous System Development Heart Development Keratan Sulfate Biosynthetic Process Proteoglycan Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Keratan Sulfate Catabolic Process
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Marimastat N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID	GM6001
Diseases		Amelogenesis imperfecta	Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Adverse response to antithyroid drugs in Graves disease ( 30067105) Neuroblastoma (11q deletion) ( 28924153) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Response to TNF inhibitor in rheumatoid arthritis (change in patient global heath assessment score) ( 30166627) Urinary metabolite levels in chronic kidney disease ( 29545352)	Age-related hearing impairment ( 27764096) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		1 interacting genes: ACAN	17 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR
Entrez ID		9313	176
HPRD ID		05218	01123
Ensembl ID		ENSG00000137674	ENSG00000157766
Uniprot IDs		O60882	P16112
PDB IDs		2JSD	4MD4
Enriched GO Terms of Interacting Partners?
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