ACAN and TNFAIP6

Number of citations of the paper that reports this interaction (PubMedID 9654129)
12

Data Source:
HPRD (in vitro)

		ACAN	TNFAIP6
Description		aggrecan	TNF alpha induced protein 6
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Extracellular Space Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Protein Binding Hyaluronic Acid Binding
	Biological Process	Skeletal System Development Cartilage Condensation Chondrocyte Development Proteolysis Cell Adhesion Central Nervous System Development Heart Development Keratan Sulfate Biosynthetic Process Proteoglycan Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Keratan Sulfate Catabolic Process	Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Migration Ovulation Neutrophil Degranulation Negative Regulation Of Inflammatory Response
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Neutrophil degranulation
Drugs		GM6001	Hyaluronic acid
Diseases		Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Age-related hearing impairment ( 27764096) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)	Blood protein levels ( 30072576 29875488 28240269) Lung cancer ( 23143601)
Interacting Genes		17 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR	3 interacting genes: ACAN THBS1 UBC
Entrez ID		176	7130
HPRD ID		01123	02680
Ensembl ID		ENSG00000157766	ENSG00000123610
Uniprot IDs		P16112	P98066
PDB IDs		4MD4	1O7B 1O7C 2N40 2PF5 2WNO
Enriched GO Terms of Interacting Partners?
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