MAPKAPK2 and ALOX5

Number of citations of the paper that reports this interaction (PubMedID 10779545)
44

Data Source:
HPRD (in vitro)

		MAPKAPK2	ALOX5
Description		MAPK activated protein kinase 2	arachidonate 5-lipoxygenase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytosol Plasma Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
	Biological Process	MAPK Cascade Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Protein Phosphorylation Leukotriene Metabolic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Response To Cytokine Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of MRNA Stability Macropinocytosis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Inner Ear Development 3'-UTR-mediated MRNA Stabilization Regulation Of Cellular Response To Heat	Leukocyte Chemotaxis Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Cytokine-mediated Signaling Pathway Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Lipid Oxidation Interleukin-18-mediated Signaling Pathway Long-chain Fatty Acid Biosynthetic Process Neutrophil Degranulation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Hepoxilin Biosynthetic Process Oxidation-reduction Process Lipoxin Biosynthetic Process
Pathways		p38MAPK events CREB phosphorylation Synthesis of Leukotrienes (LT) and Eoxins (EX) Oxidative Stress Induced Senescence Regulation of HSF1-mediated heat shock response VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs		Staurosporine 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Diacerein Rhein
Diseases
GWAS		Blood protein levels ( 28240269) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695)	Cholesterol, total ( 24097068) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Total cholesterol levels ( 28334899)
Interacting Genes		42 interacting genes: AGO2 AKT1 ALOX5 ARPC5 ATF1 BAG2 BCL2L1 BECN1 CDC25B CEP131 CREB1 DDX5 DES EEF2K ETV1 HNRNPA0 HSF1 HSPB1 LIMK1 LSP1 MAP2K6 MAPK14 MAPK3 MDM2 PABPC1 PARN PHC2 PIAS2 RCSD1 SHC1 SRF STAT3 TCF3 TH TRIM28 TRIM29 TSC2 UBE2J1 WASF1 YWHAZ ZFP36 ZFP36L1	19 interacting genes: ACTB ALOX5AP ALPL APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 MTDH NUTM1 REL SYCE1 TGFBRAP1
Entrez ID		9261	240
HPRD ID		11882	01065
Ensembl ID		ENSG00000162889	ENSG00000012779
Uniprot IDs		P49137	P09917
PDB IDs		1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3A2C 3FPM 3FYJ 3FYK 3GOK 3KA0 3KC3 3KGA 3M2W 3M42 3R2B 3R2Y 3R30 3WI6 4TYH	2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?
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