MTDH and METTL3

Number of citations of the paper that reports this interaction (PubMedID 22199357)
28

Data Source:
BioGRID (unspecified method)

		MTDH	METTL3
Description		metadherin	methyltransferase like 3
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding	MRNA (N6-adenosine)-methyltransferase Activity MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Bicellular Tight Junction Assembly Positive Regulation Of Nucleic Acid-templated Transcription	MRNA Splicing, Via Spliceosome RNA Methylation Adenosine To Inosine Editing MRNA Processing MRNA Catabolic Process Cellular Response To DNA Damage Stimulus Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome RNA Metabolic Process Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Primary MiRNA Processing Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization MRNA Methylation Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation Primary MiRNA Methylation
Pathways			Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010) Migraine ( 20802479) nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414)	Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		174 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CENPJ CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 GHDC GLG1 GRID1 HACE1 HERC5 HP1BP3 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PDCD11 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC22A18AS SLC38A4 SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 VIM WDFY2 WDR78 WNK2 ZNF559 ZXDC	5 interacting genes: EIF3G EIF3I EIF3J EIF3M MTDH
Entrez ID		92140	56339
HPRD ID		17459	14389
Ensembl ID		ENSG00000147649	ENSG00000165819
Uniprot IDs		A0A024R9D2 Q86UE4	Q86U44
PDB IDs		4QMG	5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9
Enriched GO Terms of Interacting Partners?
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