METTL3 and EIF3I

Number of citations of the paper that reports this interaction (PubMedID 30232453)
34

Data Source:
BioGRID (pull down)

		METTL3	EIF3I
Description		methyltransferase like 3	eukaryotic translation initiation factor 3 subunit I
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	MRNA (N6-adenosine)-methyltransferase Activity MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding	Translation Initiation Factor Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Methylation Adenosine To Inosine Editing MRNA Processing MRNA Catabolic Process Cellular Response To DNA Damage Stimulus Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome RNA Metabolic Process Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Primary MiRNA Processing Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization MRNA Methylation Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation Primary MiRNA Methylation	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation
Pathways		Processing of Capped Intron-Containing Pre-mRNA	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		5 interacting genes: EIF3G EIF3I EIF3J EIF3M MTDH	11 interacting genes: EIF3A EIF3B EIF4G1 ESR1 EXOSC6 LIG4 METTL3 PAXIP1 SUMO4 TGFB1 TGFBR2
Entrez ID		56339	8668
HPRD ID		14389	04884
Ensembl ID		ENSG00000165819	ENSG00000084623
Uniprot IDs		Q86U44	Q13347 Q5U0F4
PDB IDs		5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9
Enriched GO Terms of Interacting Partners?
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