DEDD and APLP2

Number of citations of the paper that reports this interaction (PubMedID 20195357)
30

Data Source:
BioGRID (pull down)

		DEDD	APLP2
Description		death effector domain containing	amyloid beta precursor like protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding
	Biological Process	Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process	Platelet Degranulation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Zinc
Diseases
GWAS			Blood protein levels ( 30072576)
Interacting Genes		16 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 KRT18 KRT8 SHMT1 SMAD3	22 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 VKORC1 ZNF512B
Entrez ID		9191	334
HPRD ID		06022	00103
Ensembl ID		ENSG00000158796	ENSG00000084234
Uniprot IDs		B1AQP5 O75618	A0A140VJE9 B4E3I5 Q06481
PDB IDs			5JBT 5TPT
Enriched GO Terms of Interacting Partners?
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