CNOT9 and GRB10

Number of citations of the paper that reports this interaction (PubMedID 20878056)
6

Data Source:
BioGRID (pull down)

		CNOT9	GRB10
Description		CCR4-NOT transcription complex subunit 9	growth factor receptor bound protein 10
Image
GO Annotations	Cellular Component	P-body Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Gene Silencing By RNA Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Nuclear Receptor Transcription Coactivator Activity	Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23512250) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378)
Interacting Genes		8 interacting genes: AKT1 CNOT1 CNOT4 EGFR GIGYF1 GIGYF2 GRB10 MYB	32 interacting genes: ABL1 AKT1 APP BAIAP2 BCR CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET SRC ZDHHC17
Entrez ID		9125	2887
HPRD ID		08828	03312
Ensembl ID		ENSG00000144580	ENSG00000106070
Uniprot IDs		D5MQE1 Q92600	Q13322
PDB IDs		2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON	1NRV 3HK0
Enriched GO Terms of Interacting Partners?
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