GRB10 and MAP3K14

Number of citations of the paper that reports this interaction (PubMedID 12853971)
17

Data Source:
HPRD (in vivo)

		GRB10	MAP3K14
Description		growth factor receptor bound protein 10	mitogen-activated protein kinase kinase kinase 14
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	MAPK Cascade Activation Of MAPKK Activity Immune Response I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling Response of EIF2AK1 (HRI) to heme deficiency	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK - noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		32 interacting genes: ABL1 AKT1 APP BAIAP2 BCR CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET SRC ZDHHC17	40 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91
Entrez ID		2887	9020
HPRD ID		03312	05230
Ensembl ID		ENSG00000106070	ENSG00000006062
Uniprot IDs		Q13322	Q68D39 Q99558
PDB IDs		1NRV 3HK0	4DN5 4G3D 4IDT 4IDV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?