USP10 and SNX3

Number of citations of the paper that reports this interaction (PubMedID 18632802)
20

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		USP10	SNX3
Description		ubiquitin specific peptidase 10	sorting nexin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ion Channel Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Protein Deubiquitination Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Regulation Of Intracellular Protein Transport Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	WNT ligand biogenesis and trafficking Ub-specific processing proteases
Drugs			S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		13 interacting genes: AR G3BP1 H2AC20 IKBKG MSH2 NOTCH1 PRKAA2 RAD51 SCNN1A SCNN1G SIRT6 SNX3 UBC	11 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A SCNN1A STX11 TSC22D2 USP10 VPS35
Entrez ID		9100	8724
HPRD ID		07029	09333
Ensembl ID		ENSG00000103194	ENSG00000112335
Uniprot IDs		Q14694	O60493
PDB IDs			2MXC 2YPS 5F0J 5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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