SNX3 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 24344282)
43

Data Source:
BioGRID (pull down)

		SNX3	VPS35
Description		sorting nexin 3	VPS35 retromer complex component
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Presynapse Glutamatergic Synapse Mitochondrion-derived Vesicle
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Protein Deubiquitination Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Regulation Of Intracellular Protein Transport Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Lysosome Organization Synapse Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Viral Process Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Homooligomerization Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Voluntary Musculoskeletal Movement Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Localization Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Retrograde Transport, Endosome To Plasma Membrane Regulation Of Terminal Button Organization
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases	WNT ligand biogenesis and trafficking
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS
Interacting Genes		11 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A SCNN1A STX11 TSC22D2 USP10 VPS35	9 interacting genes: APP MTNR1B SLC11A2 SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B
Entrez ID		8724	55737
HPRD ID		09333	06085
Ensembl ID		ENSG00000112335	ENSG00000069329
Uniprot IDs		O60493	Q96QK1
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P	2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI
Enriched GO Terms of Interacting Partners?
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