DNAJA3 and IFNGR2

Number of citations of the paper that reports this interaction (PubMedID 11679576)
14

Data Source:
HPRD (in vivo)

		DNAJA3	IFNGR2
Description		DnaJ heat shock protein family (Hsp40) member A3	interferon gamma receptor 2
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Extrinsic Component Of Plasma Membrane Cell Junction Neuromuscular Junction Intracellular Membrane-bounded Organelle Postsynaptic Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Protein Binding ATP Binding Hsp70 Protein Binding GTPase Regulator Activity Metal Ion Binding Unfolded Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitochondrial DNA Replication Protein Folding Activation-induced Cell Death Of T Cells Mitochondrion Organization Small GTPase Mediated Signal Transduction Cell Aging Negative Regulation Of Cell Proliferation Response To Heat T Cell Differentiation In Thymus Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Skeletal Muscle Acetylcholine-gated Channel Clustering	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling
Drugs			Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Erectile dysfunction ( 30583798) Schizophrenia ( 28991256) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		40 interacting genes: ATXN1 BRCA1 C2CD6 CARM1 COIL FAM131C FAM214B FBXO7 FOSL2 FRMD6 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 RAD51 RASA1 RELA RNF34 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22	8 interacting genes: ANXA5 CAMK2D DNAJA3 IFNG IFNGR1 JAK2 NR3C1 RPL37A
Entrez ID		9093	3460
HPRD ID		09758	00956
Ensembl ID		ENSG00000103423	ENSG00000159128
Uniprot IDs		B3KM81 Q53G26 Q59E88 Q96EY1	A8K881 E7EUY1 P38484
PDB IDs		2CTT 2DN9	5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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