PRC1 and RACGAP1

Number of citations of the paper that reports this interaction (PubMedID 14744859)
32

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PRC1	RACGAP1
Description		protein regulator of cytokinesis 1	Rac GTPase activating protein 1
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Spindle Cytosol Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Mitotic Spindle Elongation Microtubule Bundle Formation Positive Regulation Of Cell Proliferation Regulation Of Cytokinesis Cell Division	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Spermatogenesis Neuroblast Proliferation Sulfate Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Pathways		RHO GTPases activate CIT	Rho GTPase cycle MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Breast cancer ( 29059683 25038754) Mean platelet volume ( 27863252) Multisite chronic pain ( 31194737) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 20581827 30718926 28869590)
Interacting Genes		25 interacting genes: AKAP9 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 NDEL1 PCM1 PLK1 RACGAP1 RBM10 RPA2 SF3B2 SLAIN1 TRIM37 USHBP1 YWHAE	28 interacting genes: AURKB CDK1 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG
Entrez ID		9055	29127
HPRD ID		17899	05402
Ensembl ID		ENSG00000198901	ENSG00000161800
Uniprot IDs		A0A024RC67 O43663	A0A024R136 B2RE34 Q9H0H5
PDB IDs		3NRX 3NRY 4L3I 4L6Y 5KMG	2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?
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