CCNT1 and HEXIM1

Number of citations of the paper that reports this interaction (PubMedID 12832472)
117

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CCNT1	HEXIM1
Description		cyclin T1	HEXIM P-TEFb complex subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cyclin/CDK Positive Transcription Elongation Factor Complex	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Transcription Regulatory Region DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Viral Process Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Cell Division Negative Regulation Of MRNA Polyadenylation	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		26 interacting genes: AFF4 AHR BRD4 CDK9 CEBPB ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2 SUPT5H	10 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 RELA RN7SK TERF1 TERF2 UBE2O
Entrez ID		904	10614
HPRD ID		03938	09544
Ensembl ID		ENSG00000129315	ENSG00000186834
Uniprot IDs		A8K4M5 O60563	O94992
PDB IDs		2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH	2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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