HEXIM1 and UBE2O

Number of citations of the paper that reports this interaction (PubMedID 29845934)
4

Data Source:
BioGRID (enzymatic study)

		HEXIM1	UBE2O
Description		HEXIM P-TEFb complex subunit 1	ubiquitin conjugating enzyme E2 O
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding	RNA Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Endopeptidase Activity Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Protein K63-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mitochondrial DNA levels ( 25240745)
Interacting Genes		10 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 RELA RN7SK TERF1 TERF2 UBE2O	16 interacting genes: APPL1 BAP1 CPNE1 CPNE2 CPNE4 HEXIM1 ITCH MAF MDM2 PRKN RNF10 RNF31 SHBG TRIM27 UBC UBE2D3
Entrez ID		10614	63893
HPRD ID		09544	10928
Ensembl ID		ENSG00000186834	ENSG00000175931
Uniprot IDs		O94992	Q9C0C9
PDB IDs		2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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