HIP1R and EPN1

Number of citations of the paper that reports this interaction (PubMedID 29362354)
6

Data Source:
BioGRID (pull down)

		HIP1R	EPN1
Description		huntingtin interacting protein 1 related	epsin 1
Image
GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Apical Plasma Membrane Clathrin-coated Vesicle Actin Cortical Patch Clathrin-coated Vesicle Membrane Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Synaptic Membrane	Nucleus Cytosol Plasma Membrane Clathrin-coated Pit
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Lipid Binding
	Biological Process	Receptor-mediated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Female Pregnancy Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development Membrane Organization Negative Regulation Of Sprouting Angiogenesis
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			1,4-Diethylene Dioxide 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Body mass index ( 29273807) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990)	Major depressive disorder ( 23377640)
Interacting Genes		11 interacting genes: ACTA1 ACTB CIT CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT	24 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16
Entrez ID		9026	29924
HPRD ID		10412	06270
Ensembl ID		ENSG00000130787	ENSG00000063245
Uniprot IDs		B3KQW8 B4DPL0 O75146	A0A024R4S1 Q9Y6I3
PDB IDs		1R0D	1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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