WASL and PACSIN3

Number of citations of the paper that reports this interaction (PubMedID 11082044)
65

Data Source:
HPRD (in vitro)

		WASL	PACSIN3
Description		WASP like actin nucleation promoting factor	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Actin Cortical Patch Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding GTPase Regulator Activity Actin Filament Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity
	Biological Process	Actin Cortical Patch Assembly Endocytosis Vesicle Budding From Membrane Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Vesicle Organization Actin Filament Polymerization Actin Filament-based Movement Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein-containing Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Actin Nucleation Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Actin Cortical Patch Localization Dendritic Spine Morphogenesis Membrane Organization Protein-containing Complex Assembly Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Platelet count ( 22139419 27863252) Plateletcrit ( 27863252)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		51 interacting genes: AASS ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395	19 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 CLNK DNM1 ITSN1 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TRPV4 WASL
Entrez ID		8976	29763
HPRD ID		05448	05937
Ensembl ID		ENSG00000106299	ENSG00000165912
Uniprot IDs		O00401	Q9UKS6
PDB IDs		2FF3 2LNH 2VCP 4CC2 4CC7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?