FOXH1 and FOXG1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo)

		FOXH1	FOXG1
Description		forkhead box H1	forkhead box G1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Activin Responsive Factor Complex	Nuclear Chromatin Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Enhancer Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of Mitotic Cell Cycle Brain Development Aging Dorsal/ventral Pattern Formation Axon Midline Choice Point Recognition Pyramidal Neuron Migration Inner Ear Morphogenesis Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Neuron Fate Determination
Pathways		Signaling by NODAL Signaling by Activin	Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes
Drugs
Diseases			Rett syndrome
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Longevity ( 20834067) Manganese levels ( 26025379) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		7 interacting genes: DRAP1 FOXG1 NKX2-5 SMAD2 SMAD3 SMAD4 SOX4	19 interacting genes: APOE AR EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 SRF TLE1 TLE3 TLE6
Entrez ID		8928	2290
HPRD ID		04689	01283
Ensembl ID		ENSG00000160973	ENSG00000176165
Uniprot IDs		O75593	P55316
PDB IDs		5XOC
Enriched GO Terms of Interacting Partners?
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