FOXH1 and NKX2-5

Number of citations of the paper that reports this interaction (PubMedID 15363409)
55

Data Source:
HPRD (in vitro)

		FOXH1	NKX2-5
Description		forkhead box H1	NK2 homeobox 5
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Activin Responsive Factor Complex	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Enhancer Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction
Pathways		Signaling by NODAL Signaling by Activin	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Atrial septal defect Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Atrial fibrillation ( 30061737 29892015) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) Ischemic stroke (cardioembolic) ( 29531354) PR interval ( 30046033 20062060) Resting heart rate ( 27798624) Stroke ( 26089329)
Interacting Genes		7 interacting genes: DRAP1 FOXG1 NKX2-5 SMAD2 SMAD3 SMAD4 SOX4	14 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		8928	1482
HPRD ID		04689	02787
Ensembl ID		ENSG00000160973	ENSG00000183072
Uniprot IDs		O75593	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		5XOC	3RKQ 4S0H
Enriched GO Terms of Interacting Partners?
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