CDC16 and MAD2L1

Number of citations of the paper that reports this interaction (PubMedID 9628895)
79

Data Source:
HPRD (in vivo, in vitro)

		CDC16	MAD2L1
Description		cell division cycle 16	mitotic arrest deficient 2 like 1
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Cytosol Spindle Microtubule	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cell Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)	Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369)
Interacting Genes		23 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC27 DAB2 DNAJA1 FBXO5 FTH1 HINT1 LINC00839 MAD2L1 MTNR1B PPP5C SKIL SMAD2 SMAD3 TUBGCP3 UBE2S XRCC5	23 interacting genes: ADAM17 ANAPC2 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		8881	4085
HPRD ID		04587	03274
Ensembl ID		ENSG00000130177	ENSG00000164109
Uniprot IDs		A0A024RDZ2 A0A3B3ISD2 B2RCW0 Q13042	Q13257
PDB IDs		3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H	1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X
Enriched GO Terms of Interacting Partners?
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