STING1 and LTN1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (pull down)

		STING1	LTN1
Description		stimulator of interferon response cGAMP interactor 1	listerin E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Autophagosome Membrane Nucleoplasm Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Perinuclear Region Of Cytoplasm Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane	Cytosol RQC Complex
	Molecular Function	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding	Protein Binding Zinc Ion Binding Ribosomal Large Subunit Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Viral Process Positive Regulation Of Macroautophagy Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Cellular Response To Interferon-beta Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Protein Complex Oligomerization Defense Response To Virus Reticulophagy Cellular Response To Exogenous DsRNA Cellular Response To Organic Cyclic Compound	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 28552196) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		13 interacting genes: CCDC47 DDOST IRAK1 LTN1 MBOAT7 MUL1 RNF26 SGPL1 STT3A SURF4 TRIM32 USP20 USP49	8 interacting genes: HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3
Entrez ID		340061	26046
HPRD ID		14173	10327
Ensembl ID		ENSG00000184584	ENSG00000198862
Uniprot IDs		J3QTB1 Q86WV6 V5V0K2	O94822
PDB IDs		4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C	3J92
Enriched GO Terms of Interacting Partners?
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