HDAC3 and HDAC10

Number of citations of the paper that reports this interaction (PubMedID 11861901)
36

Data Source:
HPRD (in vivo)

		HDAC3	HDAC10
Description		histone deacetylase 3	histone deacetylase 10
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcriptional Repressor Complex Mitotic Spindle	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NF-kappaB Binding	Histone Deacetylase Activity Protein Binding Zinc Ion Binding Deacetylase Activity Enzyme Binding Protein Deacetylase Activity Histone Deacetylase Binding Acetylputrescine Deacetylase Activity Acetylspermidine Deacetylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Chromatin Organization Protein Deacetylation Circadian Rhythm Negative Regulation Of Myotube Differentiation Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Spindle Assembly Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Chromatin Organization Regulation Of Transcription, DNA-templated Protein Deacetylation Oligodendrocyte Development Macroautophagy Histone Deacetylation Positive Regulation Of Mismatch Repair Peptidyl-lysine Deacetylation Homologous Recombination Negative Regulation Of Transcription, DNA-templated Polyamine Deacetylation Spermidine Deacetylation
Pathways		NR1D1 (REV-ERBA) represses gene expression p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs		Vorinostat Belinostat Pracinostat Panobinostat Mocetinostat	Belinostat Panobinostat
Diseases
GWAS			Acne (severe) ( 24927181) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		101 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16	8 interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28
Entrez ID		8841	83933
HPRD ID		08950	09407
Ensembl ID		ENSG00000171720	ENSG00000100429
Uniprot IDs		O15379	Q969S8
PDB IDs		4A69
Enriched GO Terms of Interacting Partners?
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