HESX1 and NPAS2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HESX1	NPAS2
Description		HESX homeobox 1	neuronal PAS domain protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Protein N-terminus Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Pituitary Gland Development Otic Vesicle Formation Nose Development Forebrain Morphogenesis	Cellular Response To DNA Damage Stimulus Central Nervous System Development Circadian Rhythm Regulation Of Lipid Metabolic Process Circadian Regulation Of Gene Expression Response To Drug Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Redox State Negative Regulation Of Cell Death Positive Regulation Of Behavioral Fear Response Regulation Of Response To DNA Damage Stimulus
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Circadian Clock Circadian Clock
Drugs
Diseases		Septo-optic dysplasia Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)	Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Intraocular pressure ( 31798171 31959993 30054594) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Pulse pressure ( 27841878)
Interacting Genes		7 interacting genes: KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1	24 interacting genes: ARNT2 ARNTL CLOCK CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 KAT2B NCOA3 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 ZSCAN1
Entrez ID		8820	4862
HPRD ID		03482	09137
Ensembl ID		ENSG00000163666	ENSG00000170485
Uniprot IDs		A1LQR0 Q9UBX0	A2I2P5 Q99743
PDB IDs		2K40
Enriched GO Terms of Interacting Partners?
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