DPM2 and DPM3

Number of citations of the paper that reports this interaction (PubMedID 10835346)
44

Data Source:
HPRD (in vivo)

		DPM2	DPM3
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane Mannosyltransferase Complex Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Enzyme Regulator Activity	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity	Carbohydrate Metabolic Process GPI Anchor Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Regulation Of Protein Stability Protein Mannosylation Protein O-linked Mannosylation
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		6 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC VKORC1	2 interacting genes: DPM1 DPM2
Entrez ID		8818	54344
HPRD ID		16028	16179
Ensembl ID		ENSG00000136908	ENSG00000179085
Uniprot IDs		O94777	A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?
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