DPM2 and PIGC

Number of citations of the paper that reports this interaction (PubMedID 10944123)
38

Data Source:
HPRD (in vitro)

		DPM2	PIGC
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	phosphatidylinositol glycan anchor biosynthesis class C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Enzyme Regulator Activity	Catalytic Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)	Daytime sleep phenotypes ( 27126917) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		6 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC VKORC1	4 interacting genes: DPM2 KLF10 PIGQ ZHX1
Entrez ID		8818	5279
HPRD ID		16028	03433
Ensembl ID		ENSG00000136908	ENSG00000135845
Uniprot IDs		O94777	Q92535
PDB IDs
Enriched GO Terms of Interacting Partners?
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