ACTN2 and FBXL22

Number of citations of the paper that reports this interaction (PubMedID 22972877)
15

Data Source:
BioGRID (enzymatic study)

		ACTN2	FBXL22
Description		actinin alpha 2	F-box and leucine rich repeat protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Z Disc Filopodium Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Dendritic Spine Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Nucleolus Cytosol SCF Ubiquitin Ligase Complex Z Disc
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Protein Domain Specific Binding LIM Domain Binding Thyroid Hormone Receptor Coactivator Activity Titin Binding Identical Protein Binding Ion Channel Binding Actin Filament Binding FATZ Binding Titin Z Domain Binding	Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Platelet Degranulation Cell Adhesion Microspike Assembly Muscle Filament Sliding Regulation Of Membrane Potential Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Sarcomere Organization Focal Adhesion Assembly Actin Filament Uncapping Cardiac Muscle Cell Development Protein Localization To Plasma Membrane Phospholipase C-activating Angiotensin-activated Signaling Pathway Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Protein Localization To Cell Surface Regulation Of NMDA Receptor Activity Positive Regulation Of Endocytic Recycling Positive Regulation Of Cation Channel Activity	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Cell Cycle
Pathways		Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Periodontitis (CDC/AAP) ( 24024966)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		86 interacting genes: ACTN1 ACTN3 ADAM12 ADORA2A AKAP8L ANG ANGPTL7 ATP5MC1 ATXN2 ATXN7 BRMS1L CAMK2A CAMK2D CAMK2G CAPN1 CD27 CLEC4D COIL CRABP2 CRADD DISC1 DLG1 DLG4 EPS8L1 ERBIN FAM50B FBXL22 GATA3 GOLGA7 GRIN1 GRIN2B GSTT1 H4C9 HSPB1 ITGB3BP KAT2B KATNAL2 KCNA4 KCNA5 KCNN2 LDB3 LRP12 LRRC7 MED14 MICALL2 MOS MRPL10 MYOT MYOZ1 MYOZ2 MYOZ3 MYPN NCAPH2 NCOA2 NCOR1 NOS3 NR1I2 NRIP1 PALLD PDLIM1 PDLIM3 PKD2 PPP1CB QARS1 RACK1 RAVER1 RPL35 RTP5 SAXO1 SELE SNAI1 SNW1 SP100 SPA17 SRP9 SSX2IP ST7 SYNPO2 TCTEX1D2 TNN TOLLIP TTN UTRN ZC2HC1C ZNF446 ZNRD2	1 interacting genes: ACTN2
Entrez ID		88	283807
HPRD ID		00019	16432
Ensembl ID		ENSG00000077522	ENSG00000197361
Uniprot IDs		F6THM6 P35609 Q59FD9	Q6P050
PDB IDs		1H8B 1HCI 1QUU 4D1E 5A36 5A37 5A38 5A4B
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?