TNFRSF10C and TNFSF10

Number of citations of the paper that reports this interaction (PubMedID 9314565)
117

Data Source:
HPRD (in vivo, in vitro)

		TNFRSF10C	TNFSF10
Description		TNF receptor superfamily member 10c	TNF superfamily member 10
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Anchored Component Of Membrane	Extracellular Region Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity TRAIL Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding TRAIL Binding
	Biological Process	TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Response To Insulin Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TP53 Regulates Transcription of Death Receptors and Ligands	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252) White blood cell count (basophil) ( 27863252)	Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglycerides ( 30275531)
Interacting Genes		10 interacting genes: APOA1 LMNA LRSAM1 RAP1A RFLNB SLC27A6 SRPK1 SRPK2 TNFSF10 ZHX1	9 interacting genes: ACP5 CASP3 RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
Entrez ID		8794	8743
HPRD ID		04681	04670
Ensembl ID		ENSG00000173535	ENSG00000121858
Uniprot IDs		O14798	P50591 Q6IBA9
PDB IDs			1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?
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