TNFSF10

Description		TNF superfamily member 10
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GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Response To Insulin Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglycerides ( 30275531)
Interacting Genes		9 interacting genes: ACP5 CASP3 RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
Entrez ID		8743
HPRD ID		04670
Ensembl ID		ENSG00000121858
Uniprot IDs		P50591 Q6IBA9
PDB IDs		1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?
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