TNFRSF6B and TNFSF14

Number of citations of the paper that reports this interaction (PubMedID 11994433)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TNFRSF6B	TNFSF14
Description		TNF receptor superfamily member 6b	TNF superfamily member 14
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Apoptotic Process Immune Response Signal Transduction Positive Regulation Of T Cell Chemotaxis T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Myoblast Fusion
Pathways		TNFs bind their physiological receptors	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 18758464 28067908 23128233) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908 21297633)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)
Interacting Genes		5 interacting genes: FASLG KRTAP10-3 KRTAP10-9 TNFSF14 TNFSF15	5 interacting genes: APP LTB LTBR TNFRSF14 TNFRSF6B
Entrez ID		8771	8740
HPRD ID		04527	05157
Ensembl ID		ENSG00000243509	ENSG00000125735
Uniprot IDs		O95407	O43557
PDB IDs		3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36	4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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