TNFSF14 and TNFRSF6B

Number of citations of the paper that reports this interaction (PubMedID 11994433)
26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TNFSF14	TNFRSF6B
Description		TNF superfamily member 14	TNF receptor superfamily member 6b
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Immune Response Signal Transduction Positive Regulation Of T Cell Chemotaxis T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Myoblast Fusion	Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFs bind their physiological receptors
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 18758464 28067908 23128233) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		5 interacting genes: APP LTB LTBR TNFRSF14 TNFRSF6B	5 interacting genes: FASLG KRTAP10-3 KRTAP10-9 TNFSF14 TNFSF15
Entrez ID		8740	8771
HPRD ID		05157	04527
Ensembl ID		ENSG00000125735	ENSG00000243509
Uniprot IDs		O43557	O95407
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU	3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36
Enriched GO Terms of Interacting Partners?
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