TNFRSF14 and SERPINA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TNFRSF14	SERPINA4
Description		TNF receptor superfamily member 14	serpin family A member 4
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Adaptive Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Platelet Degranulation Negative Regulation Of Endopeptidase Activity
Pathways		Costimulation by the CD28 family Costimulation by the CD28 family TNFs bind their physiological receptors	Platelet degranulation
Drugs			Zinc Copper
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24449572 30423114 18794853 24390342 20453842) Ulcerative colitis ( 28067908 26398853 23128233 21297633)	Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	13 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		8764	5267
HPRD ID		04122	01004
Ensembl ID		ENSG00000157873	ENSG00000100665
Uniprot IDs		A0A024R052 Q92956	A0A024R6I9 P29622
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3	6F02
Enriched GO Terms of Interacting Partners?
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