TNFRSF14 and NDUFS2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TNFRSF14	NDUFS2
Description		TNF receptor superfamily member 14	NADH:ubiquinone oxidoreductase core subunit S2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Adaptive Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Costimulation by the CD28 family Costimulation by the CD28 family TNFs bind their physiological receptors	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24449572 30423114 18794853 24390342 20453842) Ulcerative colitis ( 28067908 26398853 23128233 21297633)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Granulocyte percentage of myeloid white cells ( 27863252)
Interacting Genes		30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48	5 interacting genes: APP CENPU EGR2 HMOX2 TNFRSF14
Entrez ID		8764	4720
HPRD ID		04122	04285
Ensembl ID		ENSG00000157873	ENSG00000158864
Uniprot IDs		A0A024R052 Q92956	B7Z792 O75306
PDB IDs		1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3	5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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