GPAA1 and AQP2

Number of citations of the paper that reports this interaction (PubMedID 28931009)
7

Data Source:
BioGRID (two hybrid)

		GPAA1	AQP2
Description		glycosylphosphatidylinositol anchor attachment 1	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding Tubulin Binding GPI Anchor Binding	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein Protein-containing Complex Assembly	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Attachment of GPI anchor to uPAR	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite levels ( 23093944)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		17 interacting genes: ADAMDEC1 AQP2 CACNG8 DGAT1 EIF3E GIT1 GRIK5 LRRC14 LY6E NDRG1 PIGK PIGT PIGU PIN1 PRR13 TERF2IP TONSL	25 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CERT1 CLDN7 CREB3 EEF1A1 ELL2 ERG28 GPAA1 IER3 NDFIP2 PLP2 SLC5A2 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM230 UBE2J1 VAPB
Entrez ID		8733	359
HPRD ID		04334	00141
Ensembl ID		ENSG00000197858	ENSG00000167580
Uniprot IDs		O43292	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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