AQP2 and STX8

Number of citations of the paper that reports this interaction (PubMedID 28931009)
7

Data Source:
BioGRID (two hybrid)

		AQP2	STX8
Description		aquaporin 2	syntaxin 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Integral Component Of Plasma Membrane Endomembrane System Integral Component Of Membrane SNARE Complex Late Endosome Membrane Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development	Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Interferon-gamma Regulation Of Protein Localization To Plasma Membrane
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases		Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)	Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
Interacting Genes		25 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CERT1 CLDN7 CREB3 EEF1A1 ELL2 ERG28 GPAA1 IER3 NDFIP2 PLP2 SLC5A2 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM230 UBE2J1 VAPB	18 interacting genes: ACVR1 AQP2 CALM1 CLN8 COPA CREB3 LMNA NAPA NAPG NSF STX1A STX4 STX7 TGFBR1 VPS11 VPS18 VTI1B WDR91
Entrez ID		359	9482
HPRD ID		00141	05012
Ensembl ID		ENSG00000167580	ENSG00000170310
Uniprot IDs		P41181	Q9UNK0
PDB IDs		4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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