URI1 and RPS6KB1

Number of citations of the paper that reports this interaction (PubMedID 21397856)
27

Data Source:
BioGRID (enzymatic study)

		URI1	RPS6KB1
Description		URI1 prefoldin like chaperone	ribosomal protein S6 kinase B1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Dendrite	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Junction Neuron Projection Synapse
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Transcription Corepressor Activity Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Inhibitor Activity Phosphoprotein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of Transcription By RNA Polymerase II Response To Virus Negative Regulation Of Phosphatase Activity Negative Regulation Of Phosphoprotein Phosphatase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Signal Transduction Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Long-chain Fatty Acid Import Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus
Pathways			mTORC1-mediated signalling
Drugs
Diseases
GWAS		Body mass index ( 26426971) Cerebrospinal P-tau181p levels ( 28247064) Diastolic blood pressure ( 27841878) Serum urate levels in chronic kidney disease ( 30181573)	C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)
Interacting Genes		9 interacting genes: APP ATF7 DMAP1 GTF2F2 ITCH NEDD4 POLR2E RPS6KB1 STAP1	61 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B CYB5R3 DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MARK2 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1
Entrez ID		8725	6198
HPRD ID		11943	10202
Ensembl ID		ENSG00000105176	ENSG00000108443
Uniprot IDs		O94763	P23443
PDB IDs			3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
Enriched GO Terms of Interacting Partners?
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