VPS35 and SNX1

Number of citations of the paper that reports this interaction (PubMedID 11102511)
98

Data Source:
HPRD (in vivo)

		VPS35	SNX1
Description		VPS35 retromer complex component	sorting nexin 1
Image
GO Annotations	Cellular Component	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Presynapse Glutamatergic Synapse Mitochondrion-derived Vesicle	Cytoplasm Lysosome Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding D1 Dopamine Receptor Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Lysosome Organization Synapse Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Viral Process Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Homooligomerization Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Voluntary Musculoskeletal Movement Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Localization Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Retrograde Transport, Endosome To Plasma Membrane Regulation Of Terminal Button Organization	Intracellular Protein Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis
Pathways		WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: APP MTNR1B SLC11A2 SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B	25 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ATXN7 CMTM5 EGFR F2R FUNDC1 HGS INSR LEPR PDGFRB RABAC1 REEP6 RTN3 RTN4 SASH1 SNX2 SNX6 TK1 UFD1 VPS35
Entrez ID		55737	6642
HPRD ID		06085	03171
Ensembl ID		ENSG00000069329	ENSG00000028528
Uniprot IDs		Q96QK1	Q13596
PDB IDs		2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI	2I4K 4FZS
Enriched GO Terms of Interacting Partners?
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